Neil married Agnes MacIssac. Agnes (daughter of Angus J. MacIssac and Mary Ann MacInnis) was born 1900; died 1971; was buried , Calvary Cemetery Bridgeport, Cape Breton County, Nova Scotia, Canada. [Group Sheet]

1. Marie Margaret Holmes was born 21 Jul 1927, Boston, MA; died 17 Mar 2018, Abington Manor, Phillipsburg, NJ; was buried , Bloomsbury Cemetery Greenwich Township, Warren County, New Jersey, USA.
2. Sonny Holmes